Results 51 to 60 of about 1,849,163 (313)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Organizational Studies: A Complement to the Study of Social Management Los estudios organizacionales: un complemento para el estudio de la gestión social

AD-minister, 2012
The article presents a reflection resulting from the PhD project “Construction intersubjective social management in the city of Medellin”, on the main aspects that turn the organizational studies into a complement in order to advance in the field of ...
María Edith Morales Mosquera
doaj  

Innovation in the application of digital tools for managing uncertainty : the case of UK independent film [PDF]

, 2013
This research investigates innovation in how film producers use social digital tools to engage consumers, reduce demand uncertainty and respond to the challenge of digital disruption that affects the traditional film value chain.
Franklin, M., Stoyanova Russell, Dimitrinka, Searle, Nicola, Townle, B., Searle, N., Michael Franklin, Stoyanova, Dimitrinka, Nicola Searle, Franklin, Michael Charles Bailey, Barbara Townley, Franklin, Michael, Townley, Barbara, Searle, Nicola Charlotte, Dimitrinka Stoyanova   +13 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Corpse Management in Social Insects [PDF]

International Journal of Biological Sciences, 2013
Undertaking behavior is an essential adaptation to social life that is critical for colony hygiene in enclosed nests. Social insects dispose of dead individuals in various fashions to prevent further contact between corpses and living members in a colony.
Sun, Qian, Zhou, Xuguo
openaire   +2 more sources

A Social Science Data Fusion Tool and the Data Management through e-Social Science (DAMES) Infrastructure

, 2010
The last two decades have seen substantially increased potential for quantitative social science research. This has been made possible by the significant expansion of publicly available social science datasets, the development of new analysis ...
Jones, Simon, Paul S. Lambert, Warner, Guy, Guy C. Warner, Dawson, Alison, Kenneth J. Turner, Alison S. F. Dawson, Larry Tan, Lambert, Paul, Simon B. Jones, Tan, Koon Leai Larry, Turner, Kenneth J, Blum, Jesse Michael, David N. F. Bell, Bell, David, Jesse M. Blum   +15 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Quo Vadis: Caminhos e Diálogos da Gestão Social com as Obras de Jürgen Habermas

Desenvolvimento em Questão, 2019
In this article we investigate how authors of the field of Social Management refer to the works of Jürgen Habermas and his conceptual framework. We argue from 54 mapped articles that, despite the influence of Habermas in the conception of the concept of ...
Valderí de Castro Alcântara, José Roberto Pereira, José Willer do Prado, Érica Aline Ferreira Silva   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source