Results 81 to 90 of about 1,849,163 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MODEL DEVELOPMENT FOR INNOVATION-ORIENTED ENTERPRISE MANAGEMENT
Advanced Engineering Research, 2012 Basic contradictions of the postindustrial period and the strategic and innovation management are r e vealed. The recommendations on the model improvement for the innovation - orie nted enterprise social management are form ulated.
Alexey V., Panfilov
doaj
Social Care Management, Strategy and Business Planning
, 2010 Social Care Management, Strategy and Business Planning is a comprehensive guide to strategic social care management, covering all the knowledge and skills that managers in the 21st century must have, and showing how to make theory a practical reality ...
Hafford-Letchfield, Trish
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
СОЦИАЛЬНЫЕ СТАНДАРТЫ КАЧЕСТВА ЖИЗНИ В СИСТЕМЕ УПРАВЛЕНИЯ СОЦИАЛЬНЫМ РАЗВИТИЕМ СТРАНЫ
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 Совершенствование управления социальной сферой, повышение качества жизни российского общества и создание эффективного государства обуславливают необходимость разработки теоретико-методологических подходов к исследованию системы социальных стандартов.
Elena Irekovna Beglova
doaj +1 more source
Topologies of power in China's grid-style social management during the COVID-19 pandemic. [PDF]
Secur Dialogue, 2023 Habich-Sobiegalla S, Plümmer F.
europepmc +1 more source
, 2014 In this report we start by setting the context for our scoping analysis of the role and functions of middle managers in Scotland's social services. Within this section, we discuss the challenge of identifying ‘who is a middle manager' and whether ...
Patterson, Frances, George, Carol
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
HUMANIZING OF ADMINISTRATIVE ACTIVITY
Научный вестник МГТУ ГА, 2016 The article deals with determining the basic directions of humanizing the administrative activity in organization the content of which provides a constructive dialog in the «leader-subordinate» system based on taking into account of many-sided nature of ...
O. D. Garanina, A. A. Fedyashov
doaj