Results 51 to 60 of about 7,776,710 (330)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Structural Components of Social Maturity Bachelor of Social Work

Bulletin of Luhansk Taras Shevchenko National University, 2022
The article reveals the structural components of social maturity of the bachelor of social work. The stages of social maturation of the individual are revealed. Social activity, tolerance, focus on socially significant values, creativity, reflection and social responsibility as the main components of social maturity of the bachelor of social work are ...
Serhii Konoshenko, Nataliia Konoshenko, Inna Trubnik   +2 more
openaire   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Professional maturity of policemen: theoretical aspect

Проблеми сучасної психології, 2017
The main priorities of development of the Ministry of Internal Affairs are defined in the article: the development of personnel potential and social protection of the population.
A. I. Cherkashyn
doaj  

Peran Dukungan Sosial Keluarga dalam Membentuk Kematangan Karier Siswa SMP

Jurnal Ilmu Keluarga dan Konsumen, 2018
The family is part of the process in forming student career maturity to be able to develop the career optimally. This study aimed to analyze the effect of the role of family social support on the career maturity of junior high school students and ...
Ulifa Rahma, Esti Widya Rahayu
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

SCALE SELF-ASSESSMENT OF PERSONAL MATURITY: ТНЕ EXPERIENCE IN THE DEVELOPMENT AND TESTING

Sovremennye Issledovaniâ Socialʹnyh Problem, 2017
Purpose. The article is devoted to substantive and psychometric characteristics to The Scale self-assessment of personal maturity. The scale developed on the socio-constructionist interpretation of the personal maturity’s criteria, which are considered ...
Anastasia Vladimirovna Miklyaeva
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source