Results 141 to 150 of about 14,647,295 (402)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Datafying citizens: Third-party trackers and data-as-payment in government infrastructure

open access: yesNordicom Review
Scandinavians are among the most datafied citizens in the world. With its digitalised welfare states, Danish, Norwegian, and Swedish e-governance infrastructures collect massive amounts of data about citizens as they search for jobs, apply for building ...
Sjøvaag Helle   +4 more
doaj   +1 more source

Teens, Tech, and Talk: Adolescents’ Use of and Emotional Reactions to Snapchat’s My AI Chatbot

open access: yesBehavioral Sciences
Due to technological advancements such as generative artificial intelligence (AI) and large language models, chatbots enable increasingly human-like, real-time conversations through text (e.g., OpenAI’s ChatGPT) and voice (e.g., Amazon’s Alexa).
Gaëlle Vanhoffelen   +2 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Social Media and Social Change

open access: yesDigest of Middle East Studies, 2016
AbstractThe growing impact of new media around the world has been the subject of study by scores of scientists in multidisciplinary fields. Satellite TV and the Internet have been viewed as instruments of social and political change — connecting communities, educating the youth, and creating social networks previously unaccounted for, like virtual ...
openaire   +4 more sources

Social capital and social media: the effects of Facebook use on social capital and perceived community involvement [PDF]

open access: yes, 2016
The purpose of this paper is to look at the effect of social media use on social capital. This paper attempts to establish a dichotomy between 'real' and 'perceived' social capital and the effect of social media use on both.
Schlachte, Christian
core   +1 more source

Supporting Early Childhood Preservice Teachers to Effectively Integrate STEM in Their Future Teaching Practice

open access: yesEducation Sciences
It is critical that teachers are equipped with Science, Technology, Engineering and Mathematics (STEM) skills and knowledge as we move into a digital future.
Sarika Kewalramani   +2 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Could social media improve New Save Supermarket’s Asian market segment? [PDF]

open access: yes, 2018
Social media has become a part of people’s daily life. It is a multi-functional tool for people, who use social media to communicate with others, share content, and consume information in real time.
Deng, Siting, Yeung, Deniss
core  

Adiksi Media Sosial Sebagai Penyebab Harga Diri Rendah Pada Usia Dewasa Muda [PDF]

open access: yes
The use of social media has increased in the last few years. Social media has a negative impact on a person's selfesteem because they make social comparisons based on what they see on social media.
Arfianto, Muhammad Ari   +3 more
core   +1 more source

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