Results 81 to 90 of about 28,651,409 (314)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Mining social media for newsgathering: A review [PDF]

open access: yes, 2019
Social media is becoming an increasingly important data source for learning about breaking news and for following the latest developments of ongoing news. This is in part possible thanks to the existence of mobile devices, which allows anyone with access
Zubiaga, A
core   +1 more source

La Formación Archivística en San Luís Potosí. Reflejo de una necesidad nacional

open access: yesDocumentación de las Ciencias de la Información, 2012
Este trabajo presenta, de manera general, el desarrollo de la archivística hasta alcanzar su estamento de ciencia y, por otra parte, la influencia del quehacer organizativo de los documentos existentes y su tratamiento como una ciencia y la formación de ...
Guadalupe Patricia Ramos Fandiño   +1 more
doaj  

A review of empirical research on pedagogical content knowledge in EFL and ESL contexts (2015–2024)

open access: yesCogent Education
This study reviews the literature on Pedagogical Content Knowledge (PCK) research with a focus on English as a Foreign Language (EFL) and English as a Second Language (ESL) teaching.
Yuan Jiang   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Social Media Activism

open access: yes
This book focuses on the referendums against water privatization in Italy and explores how activists took to social media, ultimately convincing twenty-seven million citizens to vote.
Cernison, Matteo
core   +1 more source

Listen to the Scientists: Effects of Exposure to Scientists and General Media Consumption on Cognitive, Affective, and Behavioral Mechanisms During the COVID-19 Pandemic

open access: yesHuman Behavior and Emerging Technologies
Throughout the COVID-19 crisis, scientists around the globe have engaged in science communication to an unprecedented degree to convey first-hand epidemiological knowledge and information on preventive measures.
Jessica M. Szczuka   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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