Results 131 to 140 of about 881,130 (297)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The role of an omnipresent pocket device : smartphone attendance and the role of user habits [PDF]

, 2013
Smartphones are convergent, always-on pocket devices that have taken up an important role in the life of their users. This warrants a closer look into how this medium is used in every-day situations.
De Marez, Lieven, Stevens, Isabelle, Verbrugge, Karel   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sleep quality mediates the relationship between problematic social media use and attention-deficit/hyperactivity symptoms

European Psychiatry
Introduction Commencing in 2019, the onset of the COVID-19 pandemic prompted an upsurge in online engagement, drawing attention to the advantages and perils associated with the use of social media.
L. R. Paulina, I. Csejtei, M. Miklósi
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Mobile Service Affordability for the Needy, Addiction, and ICT Policy Implications [PDF]

This paper links communications and media usage to social and household economics boundaries. It highlights that in present day society, communications and media are a necessity, but not always affordable, and that they furthermore open up for addictive ...
Pau, L-F.
core   +1 more source

Social Media Usage and Symptomatology in Patients with First Episode Psychosis [PDF]

, 2016
Schizophrenia is a severe complex psychiatric disorder characterized by symptoms such as auditory hallucinations, delusional thinking, diminished ability to emote and interact socially, and cognitive impairment.
Francis, Michael, Hadley, Abigail, Mehdiyoun, Nicole, Visco, Andrew   +3 more
core  

Social Media Presence & Usage in Indian Business Sector

, 2019
This research aims to study the interrelated concepts of adoption & usage of social media platforms and extend the discussion towards social media engagement and usage in different business sectors in India. Firms from five industries, banking, information technology, automobiles, telecommunications, and consumer goods in the Bombay Stock Exchange 500 ...
Vagrani, Anushruti, John, Jenny, Vigneswara Ilavarasan, P., Kar, Arpan   +3 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Impact of Cultural Familiarity on Students’ Social Media Usage in Higher Education [PDF]

, 2019
Using social media (SM) in Higher education (HE) becomes unavoidable in the new teaching and learning pedagogy. The current generation of students creates their groups on SM for collaboration.
Al-shaikhli, D., Al-shaikhli, D., Ibragimov, D., Ibragimov, D., Jin, L., Jin, L., Porter, A., Porter, A., Shpirko, M., Shpirko, M., Tarczynski, A., Tarczynski, A.   +11 more
core