Results 131 to 140 of about 222,824 (299)

Altered Physiological, Affective, and Functional Connectivity Responses to Acute Stress in Patients With Alcohol Use Disorder

Biological Psychiatry Global Open Science
Background: There is evidence that the processing of acute stress is altered in alcohol use disorder (AUD), but little is known about how this is manifested simultaneously across different stress parameters and which neural processes are involved.
Yana Schwarze, Johanna Voges, Alexander Schröder, Sven Dreeßen, Oliver Voß, Sören Krach, Frieder Michel Paulus, Klaus Junghanns, Lena Rademacher   +8 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

“Metabolic Governmentality”. Notes on Neoliberalism and Social Metabolism

, 2018
This work approaches the concepts of “social metabolism” and “organic interchange” (Stoffwecshel) used by Marx in The Capital from a triple-edge standpoint: biophysics, bioeconomics and biopolitics. The notion of “metabolic governmentality”, understood as human population´s capability to rule and regulate the activities and fluxes that constitute their
openaire   +1 more source

Social Metabolism and Hybrid Structures [PDF]

Journal of Industrial Ecology, 2011
Fischer-Kowalski, M, Steinberger, JK
openaire   +2 more sources

In situ Metabolism and Biogeography of Phototrophic Consortia [PDF]

, 2004
>>Novel bacteriochlorophyll e structures and species-specific variability of pigment composition in green sulfur bacteria>Characterization and in situ carbon metabolism of phototrophic consortia>The significance of organic carbon compounds for in situ ...
Glaeser, Jens
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Provision of Healthcare Services for Children in Iran: Common Ethical Principles and Obstacles to Successful Implementation

Acta Medica Iranica, 2018
Ethics is an essential element in the provision of healthcare services. Fundamental ethical values determine the manner in which the professional behavior is implemented in the healthcare area.
Fataneh Sadat Bathaie, Bagher Ardeshir Larijani, Farshad Farzadfar, Saharnaz Nedjat, Seyed Hassan Emami-Razavi, Maliheh Kadivar, Farzaneh Zahedi Anaraki, Peyman Zinati, Payam Roshanfekr, Alireza Olyaeimanesh, Davoud Nezamoleslami   +10 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source