Results 111 to 120 of about 25,411 (300)

Ports and media: A research project showcase

NECSUS, 2023
Vincent Baptist, Francesca Savoldi, Carola Hein, James Louis Smith, George N. Ramírez, Wyatt Moss-Wellington, Ming-yeh T. Rawnsley, Yat Ming Loo, Eileen Karmy, Judit Vidiella Pagès, Aurelio Castro-Varela   +10 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Social capital is associated with lower mosquito vector indices: secondary analysis from a cluster randomised controlled trial of community mobilisation for dengue prevention in Mexico

Population Health Metrics, 2019
Background Control of the Aedes aegypti mosquito is central to reducing the risk of dengue, zika, chikungunya, and yellow fever. Randomised controlled trials, including the Camino Verde trial in Mexico and Nicaragua, demonstrate the convincing impact of ...
Víctor Alvarado-Castro, Sergio Paredes-Solís, Elizabeth Nava-Aguilera, Arcadio Morales-Pérez, Miguel Flores-Moreno, José Legorreta-Soberanis, Esmeralda Jaimes-Néstor, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source

The ownership of assets by place-based community organisations : political rationales, geographies of social impact and future research agendas

, 2013
Received letter from journal 11 August 2014 that the paper will be appear in volume 13, issue 4 - not given page numbers (October 2014)This article calls for a more nuanced understanding of the links between the motivations, trajectories and policy ...
McKee, Kim, McKee, K., Moore, Tom, Moore, T.E.   +3 more
core   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Social Movements, Media Practices and Radical Democracy in South Africa

French Journal for Media Research, 2015
Les mouvements sociaux en Afrique du Sud, comme ailleurs, combinent les méthodes de mobilisation traditionnelles avec l'utilisation des nouvelles technologies pour mobiliser et créer des réseaux pour la justice sociale.
Chiumbu Sarah
doaj  

Machinery of dissent: Exploring the techno-social practices of modern protests

Internet Policy Review
Protest mobilisation and coordination require competences that extend beyond political leadership and communication. Technology, which has become a daily part of humanity, pushes protest leaders to obtain skills in navigating social media to achieve ...
Alesia Rudnik
doaj   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source