Results 121 to 130 of about 16,688,913 (390)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Wearing Many (Social) Hats: How Different are Your Different Social Network Personae?

, 2017
This paper investigates when users create profiles in different social networks, whether they are redundant expressions of the same persona, or they are adapted to each platform.
Chan, Hau-wen, Karamshuk, Dmytro, Lee, Dongwon, Sastry, Nishanth, Zhong, Changtao   +4 more
core   +1 more source

The Imagined Audience on Social Network Sites

, 2016
When people construct and share posts on social network sites like Facebook and Twitter, whom do they imagine as their audience? How do users describe this imagined audience? Do they have a sub-audience in mind (e.g., “friends who like reality television”
E. Litt, E. Hargittai
semanticscholar   +1 more source

An integrated bi-objective optimization model accounting for the social acceptance of renewable fuel production networks

, 2023
Tristan Becker, Michael Wolff, Anika Linzenich, Linda Engelmann, Katrin Arning, Martina Ziefle, Grit Walther   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Relationship Between Social Participation and Cognitive Function in Older Adults: The Mediating Role of Activities of Daily Living

SAGE Open
Cognitive impairments are common in older adults, and social participation’s impact on their cognitive function needs further confirmation. Based on the panel data from the five waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), this ...
Chong Zhang, Juan Xiong, Wenqi Luo, Lin Sun   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Social Network Analysis for Assessing Social Capital in Biosecurity Ecoliteracy [PDF]

, 2010
: Social Network Analysis for Assessing Social Capital in Biosecurity Ecoliteracy. Biosecurity ecoliteracy (BEL) is a view of literacy that applies ecological concepts to promote in-depth understanding, critical reflection, creative thinking, self ...
Falk, I. (Ian), Surata, S. P. (Sang), Vipriyanti, N. U. (Nyoman)   +2 more
core  

Experiences from a community advisory Board in the Implementation of early access to ART for all in Eswatini: a qualitative study

BMC Medical Ethics, 2019
Background Engaging communities in community-based health research is increasingly being adopted in low- and middle-income countries. The use of community advisory boards (CABs) is one method of practicing community involvement in health research.
Charmaine Khudzie Mlambo, Eva Vernooij, Roos Geut, Eliane Vrolings, Buyisile Shongwe, Saima Jiwan, Yvette Fleming, Gavin Khumalo   +7 more
doaj   +1 more source

Social Network Sites in Travel and Tourism: Benefits and Limitations [PDF]

, 2020
Jaroslav Kacetl, Blanka Klímová
openalex   +1 more source