Results 131 to 140 of about 753,725 (301)

Latent profile analysis of comorbidity of depression and anxiety symptoms in college students and its correlation with social networking service addiction

open access: yesShanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the comorbidity of depression and anxiety symptoms among college students and its correlation with social networking service addiction.Methods·A cross-sectional questionnaire survey was conducted among undergraduate students from ...
Li Jian, Wang Suping
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Content repositories and social networking : can there be synergies? [PDF]

open access: yes, 2008
This paper details the novel application of Web 2.0 concepts to current services offered to Social Scientists by the ReDReSS project, carried out by the Centre for e-Science at Lancaster University.
Dolby, Paul, Fish, Adrian
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

The Tone of Life on Social Networking Sites [PDF]

open access: yes, 2012
Presents survey findings about American adults' views of the social and emotional climate of social networking sites, including experiences of kind or unkind behavior, those that boosted or ended a friendship, and reactions to ...
Aaron Smith, Amanda Lenhart, Lee Rainie
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The digital glass house - Social networking and privacy [PDF]

open access: yes, 2011
Since the explosion of the Internet age, nearly 2 billion people are connected to the World Wide Web, creating seemingly limitless opportunities for communication and collaboration including social networking. Communication is virtually instantaneous and
Abidin, Arnie Shakinar   +1 more
core  

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

What happens when organisations embrace social networking? Knowledge sharing at a multinational business solutions corporation

open access: yesSouth African Journal of Information Management, 2009
Amid widespread resistance to online social networking tools, their effectiveness in promoting knowledge sharing in a knowledge-driven organisation was demonstrated in the study.
C. Stafford, M.A. Mearns
doaj  

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