Results 41 to 50 of about 232,678 (284)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Neuroscience and Law ::Complicated Crossings and New Perspectives /

, 2020
There have been extraordinary developments in the field of neuroscience in recent years, sparking a number of discussions within the legal field. This book studies the various interactions between neuroscience and the world of law, and explores how ...
Errigo, Maria Chiara., D'Aloia, Antonio.
core   +1 more source

Predicting Intentions of a Familiar Significant Other Beyond the Mirror Neuron System

Frontiers in Behavioral Neuroscience, 2017
Inferring intentions of others is one of the most intriguing issues in interpersonal interaction. Theories of embodied cognition and simulation suggest that this mechanism takes place through a direct and automatic matching process that occurs between an
Stephanie Cacioppo, Stephanie Cacioppo, Elsa Juan, George Monteleone   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Building a taxonomy of mental processes supporting social functioning to accelerate the integration between psychology and neuroscience: A commentary on Dang et al.

NeuroImage, 2022
A methodological and theoretical chasm continues to exist between social psychology and social neuroscience, particularly with respect to research relevant to understanding racial bias, social justice and inequality. We use the Dang et al.
Valerie Purdie-Greenaway, Alfredo Spagna
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The neoliberal leaning of the neuroscience discourse when it deals with mental health and learning disorders

Neurobiology of Disease
Neuroscience attracted increasing attention in mass media during the last decades. Indeed, neuroscience advances raise high expectations in society concerning major societal issues such as mental health and learning difficulties. Unfortunately, according
Cédric Brun, Thomas Boraud, François Gonon   +2 more
doaj   +1 more source

Individual differences in social information gathering revealed through Bayesian hierarchical models

Frontiers in Neuroscience, 2013
As studies of the neural circuits underlying choice expand to include more complicated behaviors, analysis of behaviors elicited in laboratory paradigms has grown increasingly difficult.
John ePearson, John ePearson, John ePearson, Karli K Watson, Karli K Watson, Karli K Watson, Jeffrey T Klein, R Becket Ebitz, R Becket Ebitz, R Becket Ebitz, Michael L Platt, Michael L Platt, Michael L Platt, Michael L Platt   +13 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Social Psychology and Neuroscience: Strange Bedfellows or a Healthy Marriage? [PDF]

, 2011
In this paper, we assess what neuroscience theory and method have contributed to the study of group processes and intergroup relations and what we see as potential future contributions to the discipline.
Pearson, Adam R., Orr, Patrick, Dovidio, John F.   +2 more
core   +1 more source