Results 111 to 120 of about 372,984 (305)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The cultural evolution of age-at-marriage norms [PDF]
We present an agent-based model designed to study the cultural evolution of age-at-marriage norms. We review theoretical arguments and empirical evidence on the existence of norms proscribing marriage outside of an acceptable age interval.
Alexia Prskawetz +2 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Incentives and Social Norms in Household Behavior
In a broad psychological perspective, both economic incentives and social norms may be be regarded as giving rise to purposesful, or “rational” behavior.
Lindbeck, Assar
core
Social Norms and Preferences, Chapter for the Handbook for Social Economics, Edited by J. Benhabib, A. Bisin and M. Jackson [PDF]
Social norms are often posited as an explanation of differences in economic behavior and performance of societies that are difficult to explain by differences in endowments and technology. Economists are often reluctant to incorporate social aspects into
Andrew Postlewaite
core
Understanding Consumers’ Willingness to Pay for Low-Carbon Products
SAGE OpenSocial norms are informal rules governing group behavior, and they strongly motivate the formation of low-carbon purchasing habits. Drawing on Stimulus-Organism-Response theory (SOR theory), this study surveyed 499 consumers via questionnaires.
Shuang Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Social capital, social norms and the New Institutional Economics
Douglass North (1990) describes institutions as the rules of the game that set limits on human behavior, now a universally-accepted definition. North and others especially underline the crucial role of informal social norms.
Keefer, Philip, Knack, Stephen
core
On the robustness of social norm elicitation
Journal of the Economic Science AssociationAbstractWe study the robustness of Krupka and Weber's method (2013) for eliciting social norms. In two online experiments with more than 1200 participants on Amazon Mechanical Turk, we find that participants’ response patterns are invariant to differences in the salience of the monetarily incentivized coordination aspect.
openaire +3 more sources