Results 81 to 90 of about 372,984 (305)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Institutions, Social Norms and Well-being [PDF]

This paper discusses the intrinsic and instrumental value of governance and social norms to the well being of New Zealanders. The interaction between informal social norms and formal institutions is also discussed.
Murray Petrie
core  

Serotonin and social norms : tryptophan depletion impairs social comparison and leads to resource depletion in a multiplayer harvesting game [PDF]

, 2014
How do people sustain resources for the benefit of individuals and communities and avoid the tragedy of the commons, in which shared resources become exhausted?
Rogers, Robert D., Cowen, P. J., Behrens, Timothy E. J., Cowen, P.J., Bilderbeck, A.C., Brown, G.D.A., Cowen, PJ, Rogers, RD, Behrens, T.E.J., Bilderbeck, Amy C., Brown, G.D., Behrens, T.E., Behrens, TE, Woolrich, Mark W., Brown, GD, Woolrich, M., Read, Judi, Woolrich, M, Bilderbeck, AC, Rogers, R.D., Read, J, Brown, G. D. A. (Gordon D. A.), Rogers, R., Read, J.   +23 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Social norms and optimal incentives in firms [PDF]

This paper deals with the interplay between economic incentives and social norms in firms. We outline a simple model of team production and provide preliminary results on linear incentive schemes in the presence of a social norm that may cause multiple ...
Kübler, Dorothea, Huck, Steffen, Weibull, Jörgen   +2 more
core  

The effects of a social norms marketing message on self-reported drinking behaviors of college students [PDF]

, 2001
Plan BThis pilot study investigated the immediate effects of providing college students with social norms messages regarding peer alcohol consumption on a self-report measure of drinking behaviors.
Siders, Jennifer J.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Identifying Social Norms Using Coordination Games: Why Does Dictator Game Sharing Vary? [PDF]

We explore the influence of social norms on behavior. To do so, we introduce a method for identifying norms, based on the property that social norms reflect social consensus regarding the appropriateness of different possible behaviors.
Weber, Roberto A., Krupka, Erin L.
core  

Distinguishing fast change in social norms and slow change in personal norms in cooperative decision-making

Frontiers in Psychology
Psychological research on norms has shown that norms are highly relevant for individuals’ decision-making. Yet, there is so far little understanding of how norms change over time.
Marlene C. L. Batzke, Andreas Ernst
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source