FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Risk analysis in social housing delivery: A public–private partnerships approach
, 2022 Lee‐Yun Chiang +4 more
openalex +2 more sources
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Building a Culture of Health by Creating Opportunities for Boys and Young Men of Color, Executive Summary [PDF]
, 2016 There is a long list of social, institutional, and economic barriers that prevent too many boys and young men of color from reaching their full potential.
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Manganism – Unusual Presentation at Memory Assessment Service
BJPsych OpenAims: More than 200,000 clients are referred to memory assessment annually in the United Kingdom. Alzheimer’s disease and vascular brain injury are found to be the main causes for the memory impairment among these clients.
Thilini Ranasinghe
doaj +1 more source
What are the perceived benefits of an adoption support package using video interaction guidance with prospective adopters? An exploratory study [PDF]
, 2010 "An adoption support package using video interaction guidance (VIG) with a focus on child-led play was provided by two educational psychologists to eight prospective adopters with whom a pre-school child had been placed recently.
Feltham-King, Caroline
core
Effectiveness of a health-social partnership program for discharged non-frail older adults: a pilot study. [PDF]
BMC Geriatr, 2020 Wong AKC +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source