Results 31 to 40 of about 2,546,610 (243)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Effectiveness of Corporate Social Media Activities to Increase Relational Outcomes [PDF]

, 2015
This study applies social media analytics to investigate the impact of different corporate social media activities on user word of mouth and attitudinal loyalty.
Beck, Roman, Risius, Marten
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

We Are Not Alone: Perception and The Others [PDF]

, 2018
In this paper, I have outlined an original Metaphysics of Perception which takes into consideration some of the most common views about perception in the contemporary debate.
Bucci, Andrea
core  

Adult Education Confronting White Christian Nationalism: A Thematic Analysis

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT As a way to conclude, this article elaborates key themes that emerged from the collected articles in this volume. Each article carries its own important message about the role of adult education in confronting White Christian nationalism, while here, Prins and Carr‐Chellman offer a thematic interpretation of the volume as a whole. These themes
Esther Prins, Davin Carr‐Chellman
wiley   +1 more source

Stereotactic radiosurgery for multiple small brain metastases using gamma knife versus single‐isocenter VMAT: Normal brain dose based on lesion number and size

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The study evaluates rapid linear accelerator (Linac) single isocenter stereotactic radiosurgery (SRS) with Hyperarc for large target numbers. We compared to Gamma Knife (GK), which suffers from long treatment times and investigated causes of differences. Methods Linac SRS and GK treatment plans for patients receiving 18 Gy to the gross
Abram Abdou, Timoteo Almeida, Elizabeth Bossart, Irene Monterroso, Eric A. Mellon   +4 more
wiley   +1 more source

Joint perception: gaze and beliefs about social context [PDF]

, 2010
The way that we look at images is influenced by social context. Previously we demonstrated this phenomenon of joint perception. If lone participants believed that an unseen other person was also looking at the images they saw, it shifted the balance of ...
Richardson, Daniel C., Street, Chris N. H., Tan, J.   +2 more
core   +1 more source

Toward a human‐centric co‐design methodology for AI detection of differences between planned and delivered dose in radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Many artificial intelligence (AI) solutions have been proposed to enhance the radiotherapy (RT) workflow, but limited applications have been implemented to date, suggesting an implementation gap. One contributing factor to this gap is a misalignment between AI systems and their users.
Luca M. Heising, Frank Verhaegen, Stefan G. Scheib, Maria J. G. Jacobs, Carol X. J. Ou, Viola Mottarella, Yin‐Ho Chong, Mariangela Zamburlini, Sebastiaan M. J. J. G. Nijsten, Ans Swinnen, Michel Öllers, Cecile J. A. Wolfs   +11 more
wiley   +1 more source

Teachers Social Feedback on Test Performance of Primary School Pupils [PDF]

, 2013
This study investigated the effect of teachers’ social feedback on test performance of pupils. The study adopted the between-subject experimental design. Social feedback perception scale (SFPS) was designed and employed to measure the effect of teacher’s
Adekeye, Olujide A, Adeusi, Sussan O
core