Results 161 to 170 of about 13,602,939 (296)

Eco-social policies, capitalism and the horizon of emancipatory politics. [PDF]

Crit Soc Policy
Laruffa F.
europepmc   +1 more source

The Realist Approach to Social Policies (RASP) study: A study protocol for mixed-methods realist research combined with institutional action research, to reduce socioeconomic health inequalities through systems change

, 2023
Berkel Jv, de Bruijn E, Waardenburg M, Grouw Yl, Bennekom Ev, Horst Hvd, Tonnon S, Haggenburg-Mohammed M, Haveman A, Madern T, Knoef M, de Vet E.   +11 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Reproductive and Social Policies, Sociopolitical Stress, and Implications for Maternal and Child Health Equity. [PDF]

Curr Environ Health Rep
Eick SM, Eatman JA, Chandler M, Brooks NR.   +3 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Social Policy

, 2013
openaire   +5 more sources

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Mental health-related structural stigma and discrimination in health and social policies in Nepal: A scoping review and synthesis - ERRATUM. [PDF]

Epidemiol Psychiatr Sci
Gurung D, Neupane M, Bhattarai K, Acharya B, Gautam NC, Gautam K, Koirala S, Marahatta K, Gurung P, Khadka KB, Kohrt BA, Thornicroft G, Gronholm PC.   +12 more
europepmc   +1 more source

Family policies and fertility in Europe: fertility policies at the intersection of gender policies, employment policies and care policies [PDF]

This article explores the relationship between family policies, fertility, employment and care. It suggests that similar family policies are likely to exert different effects in different contexts.
Gerda R. Neyer
core  

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source