Results 201 to 210 of about 11,260,992 (354)

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

open access: yesAdvanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera   +12 more
wiley   +1 more source

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

open access: yesAdvanced Science, EarlyView.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani   +20 more
wiley   +1 more source

Social Policy Responses to the Covid-19 Crisis in China in 2020. [PDF]

open access: yesInt J Environ Res Public Health, 2020
Lu Q, Cai Z, Chen B, Liu T.
europepmc   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

open access: yesAdvanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang   +15 more
wiley   +1 more source

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