Results 151 to 160 of about 18,837,286 (349)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Prepared for Practice? Exploring and Evaluating the First Six Months of Post-qualified Practice in Social Work [PDF]

open access: yes, 2009
This project explores how effective the Social work degree has been in enabling graduates to feel prepared for the practice of social work. Quantitative and qualitative data from online questionnaires and interviews with twelve graduates revealed that ...
Cooper, Barry   +3 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Analyzing the Utility of Openalex to Identify Studies for Systematic Reviews: Methods and a Case Study

open access: yesCochrane Evidence Synthesis and Methods
Open access scholarly resources have potential to simplify the literature search process, support more equitable access to research knowledge, and reduce biases from lack of access to relevant literature.
Claire Stansfield   +4 more
doaj   +1 more source

Learning in the Panopticon: ethical and social issues in building a virtual educational environment [PDF]

open access: yes, 2008
This paper examines ethical and social issues which have proved important when initiating and creating educational spaces within a virtual environment.
Clough, G., Ferguson, R., Sheehy, K.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The `Social' in Social Work Practice

open access: yesInternational Social Work, 2003
Byneglecting the religious dimension, social work practice has not only negated its social roots, but also deprived both client and worker of a valuable source of help. Chinese shamanic healing is contrasted with casework practice and implications are drawn for re-establishing the `social' dimension in social work practice.
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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