Results 121 to 130 of about 3,389,027 (309)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Theories of practice and geography [PDF]
, 2011 Recent developments in theories of practice have seen place and space taken explicitly into account. In particular, THEODORE SCHATZKI’s ‘site ontology’ offers distinctive but as yet under-explored means of engaging with human geographies.
Everts, J., Lahr, M., Watson, M.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Art as a Social Study: Theory into Practice [PDF]
, 1985 The concept of dialogue is one that is rarely applied in art education. The attitude prevails that teachers of art know what is best, that students are ignorant of real art, that student aesthetic experiences are trivial or worthless, and so they, the ...
Chalmers, Graeme
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Everyday mobility and citizenship: a living lab approach
Urban, Planning and Transport ResearchIn the context of a living lab that aimed to reduce everyday car use, citizens in a newly established semi-urban residential area in Sweden were asked to travel less by car, try mobility and accessibility services, and to reason about travelling and ...
Malin Henriksson +2 more
doaj +1 more source
The value of social practice theory for implementation science: learning from a theory-based mixed methods process evaluation of a randomised controlled trial. [PDF]
BMC Med Res Methodol, 2020 Frost J +7 more
europepmc +1 more source
A Call To Combine Rhetorical Theory and Practice in the Legal Writing Classroom [PDF]
, 2011 The theory and practice of law have been separated in legal education to their detriment since the turn of the twentieth century. As history teaches us and even the 2007 Carnegie Report perhaps suggests, teaching practice without theory is as inadequate ...
Robbins-Tiscione, Kristen Konrad
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Frontiers in Sustainable Food SystemsA transition toward more sustainable and just food system is necessary to address global greenhouse gas emissions and inequitable food access. Alternative food networks have emerged as a solution to counteract the adverse impacts of conventional food ...
Soumya Keefe, Jean Lee
doaj +1 more source