Results 91 to 100 of about 11,393,107 (344)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

Advanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis, Kaoutar Radi, Zifan Wang, Dennis M. Kochmann   +3 more
wiley   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Analysis of the Role of Moderating Socio-Cultural Pressure for Weight Loss and Physical Changes in Obese and Normal Weight Adolescents

Фізичне виховання, спорт і культура здоров’я у сучасному суспільстві, 2020
Topicality. Obesity is a global epidemic. Obesity is on the rise in developing countries due to changes in lifestyle. The Aim of the Research.This study aimed to compare body image problems and social-physical anxiety in obese and normal-weight ...
Seyed Mohammad Hossein Hosseini Ravesh
doaj   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

Advanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal, Mimololorun Lucy Aiyelari, Martin Dirauf, Pavel Gurikov   +3 more
wiley   +1 more source

Understanding Zillennials Consumer Green Behavior of Reducing Plastic Bag Use through the Theory of Planned and Interpersonal Behavior

Journal of Consumer Sciences
Adopting cloth bags over single-use plastic bags is a significant consumer behavior. Employing the theory of of planned and interpersonal behavior, this study aimed to understand the relationship between customers' intentions to use cloth bags and their
Nihayatu Aslamatis Solekah, Tanti Handriana, Indrianawati Usman   +2 more
doaj   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Divergent effects of listening demands and evaluative threat on listening effort in online and laboratory settings

Frontiers in Psychology
ObjectiveListening effort (LE) varies as a function of listening demands, motivation and resource availability, among other things. Motivation is posited to have a greater influence on listening effort under high, compared to low, listening demands ...
Peter J. Carolan, Peter J. Carolan, Antje Heinrich, Antje Heinrich, Kevin J. Munro, Kevin J. Munro, Rebecca E. Millman, Rebecca E. Millman   +7 more
doaj   +1 more source

Self-regulation promotes cooperation in social networks [PDF]

arXiv, 2018
Cooperative behavior in real social dilemmas is often perceived as a phenomenon emerging from norms and punishment. To overcome this paradigm, we highlight the interplay between the influence of social networks on individuals, and the activation of spontaneous self-regulating mechanisms, which may lead them to behave cooperatively, while interacting ...
arxiv  

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe

Molecular Oncology, EarlyView.
Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns, Ulrik Ringborg, Julio Celis, Bengt Jönsson, Michael Baumann   +4 more
wiley   +1 more source