Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Relevance of Health-Related Hashtags on Twitter: A Text Mining Approach [PDF]
, 2020 BACKGROUND Social media platforms facilitate user interaction and impact decision making. Users prefer to use hashtags while sharing posts. Knowing the sentiment towards diabetes, bloodpressure, and obesity is fundamental to understanding the impact of ...
Dalal, Mauli, Osei-Bryson, Kweku-Muata
core +1 more source
Perception of low social pressure and lack of capacity reduces vaccination compliance - The case of lumpy skin disease. [PDF]
Transbound Emerg Dis, 2022 Morgenstern M, Sok J, Klement E.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A comparison study looking at the impact of staff personality on recruitment and retention of staff working with children with complex disabilities and challenging behaviour, in a social care setting and an education setting [PDF]
, 2009 "This report is part of CWDC’s Practitioner-Led Research (PLR) programme. Now in its third year, the programme gives practitioners the opportunity to explore, describe and evaluate ways in which services are currently being delivered within the ...
Henshall, Annelies
core
Law Enforcement Pathways to Mental Health: Secondary Traumatic Stress, Social Support, and Social Pressure. [PDF]
J Police Crim Psychol, 2022 Daniel AM, Treece KS.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Structuring the decision process [PDF]
, 2010 This chapter includes a discussion of leadership decisions and stress. Many leaders are daily exposed to stress when they must make decisions, and there are often social reasons for this.
Selart, Marcus
core +1 more source
Journal of Consumer SciencesAdopting cloth bags over single-use plastic bags is a significant consumer behavior. Employing the theory of of planned and interpersonal behavior, this study aimed to understand the relationship between customers' intentions to use cloth bags and their
Nihayatu Aslamatis Solekah +2 more
doaj +1 more source