Results 71 to 80 of about 2,728,948 (351)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Toplumun Birlik Ve Beraberliğine Katkı Sağlayan Bazı Sufi Deneyimler (Kesrette Vahdet)

open access: yesCumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2008
Toplumun birlik ve beraberlik içinde yaşamasını, sosyal· dayanışmasını, kardeşlik duygularının pekiştirilmesini sağlayan dinamiklerimizden biri de tasavvuf erbabı ve onların söylemleridir.
ÖMER YILMAZ
doaj  

The Impact of Social Pressure on Men's Mental Health - Analysis of Social Expectations from the Perspective of Clinical Psychology

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej
The article discusses the impact of social pressure on men's mental health, paying special attention to social expectations from the perspective of clinical psychology. Social pressure, which is a set of norms, values and expectations imposed by family,
Anna Podolak   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Roscas as Financial Agreements to Cope with Social Pressure [PDF]

open access: yes
In developing countries, traditional social obligations often press rich individuals to share their income. In this paper, we posit a "model of social pressure" in which people can sign binding financial agreements amongst themselves, thereby forming ...
Nicolas Treich, Stefan Ambec
core  

Introduction à la Sociologie Générale

open access: yesSociologies, 2009
Henri Janne’s text first published in Revue de l'Institut de Sociologie, 1951, n°3, pp. 345-392, and published here with the kind authorisation of the journal.
Henri Janne
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

New nomads: the dispossession of the consumer in social housing [PDF]

open access: yes, 2011
With the advent of flexible tenancies, marketised rents, the abolition of a consumer-focused regulator and the disbanding of the National Tenant Voice, three decades of efforts to induce consumer pressure in the English social housing sector have been ...
Bradley, Q
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

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