Results 41 to 50 of about 1,382,725 (274)

Inequality of Social Problems Related to the Management and Utilization of Household Waste: Seen from the Perspective of Family Education

Gagasan Pendidikan Indonesia, 2023
Household waste management is an important aspect of sustainable living, which has an impact on environmental welfare and public health. However, the extent to which different socio-economic groups engage in responsible waste management practices varies ...
Nurul Hayat, Rahmawati Rahmawati, Ibnu Razak, Mokete Nyaphisi Bendly   +3 more
doaj   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

An Error-Correction Model for Information Transmissions of Social Networks [PDF]

arXiv, 2023
We study the error-correction problem of the communication between two vertices in a social network. By applying the concepts of coding theory into the Social Network Analysis (SNA), we develop the code social network model, which can offer an efficient way to ensure the correctness of the message transmission within the social netwoks.
arxiv  

“Failures of the State”: Factors of Formation and Mechanisms of Influence on Economic Processes

Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 3, Èkonomika,Èkologiâ, 2014
The article is devoted to the problem of genesis and influence on real economic processes of “failures of the state”. The article designates the objective functions inherent in the state the realization of which can increase the efficiency of economic ...
Gontar Nikolay Vladimirovich
doaj   +1 more source

Trauma from Armed Conflict and the Effect on Mental Health in Thailand's Deep South: A Systematic Review [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: The Deep South region of Thailand has faced a situation of jihadist insurgency since 2004 with indiscriminate attacks on civilians and more than 19,000 casualties as of September 2016.
Wit Wichaidit
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Intercompany training as production pedagogical process

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016
The article explains the corporate training as a coordinated interaction of educational and industrial processes in the preparation of in-demand professionals.
Evgeny A. Korchagin, Rais S. Safin, Adelya I. Tuyusheva   +2 more
doaj