Results 221 to 230 of about 430,868 (306)

Predictors of Green Behavior Among Hospital Nurses: Organizational Climate, Team Climate, and Awareness of Consequences. [PDF]

Int Nurs Rev
Lee SE, Lim H, Nam S, Dahinten VS.
europepmc   +1 more source

Referral to and Engagement with Pulmonary Rehabilitation: A Review and Strategic Behavioural Analysis of Factors Influencing Behaviour and Intervention Opportunities. [PDF]

Int J Chron Obstruct Pulmon Dis
Moore AP, Reardon I, Ramkissoon O, Early F, Payerne E, Ashford PA, Holmes S, Kelly MP, Singh SJ, Habib GMM, Fuld J, Lorencatto F, UPTURN Team.   +12 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Between guidelines and reality: expert neurologists' perspectives on structural resources for ALS care in Germany. [PDF]

Neurol Res Pract
Linse K, Lulé D, Schöberl F, Reilich P, Ilse B, Metelmann M, Eickhoff C, Bublitz S, Lorenzl S, Boentert M, Petri S, Rödiger A, Smesny U, Wolf J, Weyen U, Zeller D, Dorst J, Maier A, Meyer T, Lingor P, Hermann A, Regensburger M, Großkreutz J, Runge C, Lapp HS, Freigang M, Vidovic M, Aust E, Weber C, Günther R.   +29 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Scoping review of mental health-related policies issued in the context of the COVID-19 pandemic in Peru. [PDF]

PLOS Ment Health
Cavero V, Vilela-Estrada AL, Paredes-Angeles R, Cusihuaman-Lope N, Villarreal-Zegarra D, Diez-Canseco F.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The 'equity turn' and bereavement: From rhetoric to realisation. [PDF]

Palliat Care Soc Pract
Bindley K.
europepmc   +1 more source