Results 111 to 120 of about 8,101,703 (298)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

open access: yesAdvanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong   +5 more
wiley   +1 more source

Social facilitation and bilingual cognitive advantage: Bridging social psychology and psycholinguistics. [PDF]

open access: yesHeliyon, 2023
Bennani A   +5 more
europepmc   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

open access: yesAdvanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao   +10 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

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