Results 171 to 180 of about 6,260,344 (295)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

One Model, Many Cities: A Transferable Social Relationship Inference Framework for Human Mobility Data. [PDF]

Proc ACM SIGSPATIAL Int Conf Adv Inf
Chu C, Shahabi C, Tung E, Shafique K.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Social relationship challenges perceived by cancer patients and survivors: a qualitative meta-synthesis. [PDF]

BMC Psychol
Zarei B, Kazemi A, Bahrami M, Beigi-Harchegani H.   +3 more
europepmc   +1 more source

Association of self-rated health with chronic disease, mental health symptom and social relationship in older people. [PDF]

Sci Rep, 2021
Yang H, Deng Q, Geng Q, Tang Y, Ma J, Ye W, Gan Q, Rehemayi R, Gao X, Zhu C.   +9 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Development of the Social Relationship Expectations Scale: protocol for a multi-country, multi-method observational study. [PDF]

BMJ Open
Akhter-Khan SC, Ell T, Buck L, Haucke M, Luchetti M, Li L, Ong A, Chua KC, Mayston R, Prina M, Liu S, Wong G.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Neural systems for processing social relationship information along two principal dimensions. [PDF]

Commun Biol
Kang W, Kwon M, Lee SH.
europepmc   +1 more source

Social relationship quality, depression and inflammation: A cross-cultural longitudinal study in the United States and Tokyo, Japan. [PDF]

Int J Soc Psychiatry, 2022
Kaveladze B, Diamond Altman A, Niederhausen M, Loftis JM, Teo AR.   +4 more
europepmc   +1 more source