Results 191 to 200 of about 21,515,074 (353)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Under-Reporting of Transfers in Household Surveys: Its Nature and Consequences [PDF]

High rates of understatement are found for many government transfer programs and in many datasets. This understatement has major implications for our understanding of economic well-being and the effects of transfer programs.
Wallace K. C. Mok, Bruce D. Meyer, James X. Sullivan   +2 more
core  

Development of a multicomponent intervention to improve medication error reporting among healthcare professionals: a theory-informed approach using the behaviour change wheel and the theoretical domains framework in China. [PDF]

Front Pharmacol
Guo H, Guo Q, Wang Z, Wang H.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Reporting on social issues

The second ESG pillar addresses social issues related to the impacts, risks and opportunities of an organization’s relationships with individuals and groups.
Marisa Agostini
core  

Business reporting: how transparency becomes a justification mechanism [PDF]

This paper contributes to the discussion of the present status and future scenarios of business reporting by conducting a thorough review and analysis of state-of-the-art of the authoritative business reporting literature and also a set of specifically ...
Nielsen, Christian
core  

Digital Tools to Support Mental Health in Later Life: Scoping Review of Systematic Reviews. [PDF]

Curr Psychiatry Rep
Stowell M, Dobson R, Bunkley N, McCool J, Nosa V, Whittaker R.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Social Media Report

social media ...
  +6 more sources

Social Report (Társadalmi riport) 2018 and Hungarian Social Report 2019 [PDF]

Corvinus Journal of Sociology and Social Policy, 2019
openaire   +1 more source