Results 151 to 160 of about 5,212,449 (312)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Scottish Social Attitudes Survey, 2021-2022
copyright UK Data Service and data collection copyright owner.The Scottish Social Attitudes (SSA) survey was launched by ScotCen Social Research (formerly the Scottish Centre for Social Research) in 1999, following the advent of devolution.
ScotCen Social Research
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Evaluation of the Airdrie and Hamilton Youth Court Pilots - Research findings [PDF]
, 2006 Pilot Youth Courts were introduced at Hamilton Sheriff Court in June 2003 and at Airdrie Sheriff Court in June 2004. They are targeted at alleged offenders aged 16 and 17 (and appropriate 15 year olds) who are resident in areas of North and South ...
Piacentini, Laura +11 more
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Hermenêutica de Profundidade na pesquisa social
Ciências Sociais Unisinos, 2006 The paper analyzes the potentials of Depth Hermeneutics (DH), a theoretical and methodological framework developed John B. Thompson, for research and analysis in social science.
Marilia Veríssimo Veronese +1 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
New measures of consistency and coverage for social research based on neutrosophic logic [PDF]
Neutrosophic Sets and SystemsThe mathematical methods systematically used in social sciences often rely on statistical tools like correlation, which may not optimally model social phenomena, frequently described using words. Set theory, as proposed by C.C.
Erick Gonzalez Caballero +3 more
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Bayes factor testing of equality and order constraints on measures of association in social research. [PDF]
J Appl Stat, 2023 Mulder J, Gelissen JPTM.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source