Results 181 to 190 of about 35,193,888 (347)

Editorial: Theories, methods, practices, and fields of digital social research. [PDF]

Front Sociol
Addeo F, Delli Paoli A, Punziano G.
europepmc   +1 more source

Comprehensive Clinical and Social Research at the Moscow Research Institute of Psychiatry: Translation into Clinical Practice. [PDF]

Consort Psychiatr, 2021
Shmukler AB, Movina LG, Papsuev OO, Salnikova LI, Shashkova NG, Kiryanova EM.   +5 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Correction: Conflicting 'mother-scientist' roles. An innovative application of basket analysis in social research. [PDF]

PLoS One
Krause E, Tomaszewska R, Pawlicka A.
europepmc   +1 more source

Coronavax: preparing community and government for COVID-19 vaccination: a research protocol for a mixed methods social research project. [PDF]

BMJ Open, 2021
Attwell K, Carlson S, Tchilingirian J, Harper T, McKenzie L, Roberts L, Rizzi M, Westphal D, Effler P, Hughes C, Swift V, Blyth CC.   +11 more
europepmc   +1 more source

When the snowball fails to roll and the use of ‘horizontal’ networking in qualitative social research

, 2018
A. Geddes, Charlie Parker, S. Scott
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ethics in social research, its absences, urgencies, and possibilities: Critical proposals from Latin America. [PDF]

Salud Colect
Muñoz Martínez R.
europepmc   +1 more source

Algorithmic bias in social research: A meta-analysis. [PDF]

PLoS One, 2020
Thiem A, Mkrtchyan L, Haesebrouck T, Sanchez D.   +3 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source