Results 91 to 100 of about 86,387 (302)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
GLOBAL IMBALANCES, RISKS AND ECONOMIC SECURITY OF RUSSIA
Финансы: теория и практика, 2017 Article Retracted.This paper proposes an approach to the study of the impact of global imbalances and external economic risks for the Russian economy and its level of economic security.
V. K. Senchagov, A. I. Soloviev
doaj
Social representations and social cognition [PDF]
, 2014 In the present article we discuss two of the most important social psychology perspectives: social cognition (SC) perspective and socio-cognition perspective. Represented by its most emblematic theory, the Social Representations Theory (SRT).
Lima, Marcus Eugênio Oliveira +1 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 1981 The article contains an analysis of some more general present-day problems of researches on teachers as well as presentation of findings of researches conducted in one of Poland's administrative provinces.
Woskowski, Jan
core +1 more source
Management instrumentarium of innovation development of medium-sized industrial enterprises
SHS Web of Conferences, 2017 The article is devoted to the development management of industrial enterprises related to medium-sized businesses and working in the field of product innovation.
Ismagilova L., Sitnikova L., Klimova N.
doaj +1 more source
Social technologies and socialization of research [PDF]
Journal of Science Communication, 2009 Whether we like it or not, and how many difficulties this may pose, scientific research and technology are becoming the “property” of everybody and increasingly will become subject of public guidance and political decision making. Socialization happens because what people think, want and do has become central to the development of science and ...
openaire +2 more sources