Results 111 to 120 of about 5,410,250 (357)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
GeriatricsBackground/Objectives: The COVID-19 pandemic placed an immense burden on nursing home staff, significantly increasing their workload. How the impact of these challenges on job satisfaction is mitigated by personal and social resources, along with ...
Elisabeth Diehl +4 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Resourcing social enterprises: approaches and challenges [PDF]
This is the second publication from the Bankwest Foundation Social Impact Series and includes preliminary findings from the Supporting Development and Growth in the Community Sector in Western Australia research program.
Chris Mason, Jo Barraket, Sharine Barth
core +1 more source
The Social Banditry in the Rural Areas of Rembang by the End of the 19th Century and at the Beginning of the 20th Century [PDF]
, 2011 The social banditry is the act of crime committed by the residents of a village or the people in the low economic and social stratum in order to fulfill their basic needs.
Warto,
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Making Social Work Work: Improving social work for vulnerable families and children without parental care around the world: A literature review [PDF]
, 2012 This literature review calls for families and children in developing countries to be supported in ways that are appropriate to the conditions, culture and resources available rather than through approaches to social work that are common in the west ...
Bilson, Andy, Westwood, Joanne Louise
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
GCB Bioenergy, 2019 Short rotation plantations are often considered as holding vast potentials for future global bioenergy supply. In contrast to raising biomass harvests in forests, purpose‐grown biomass does not interfere with forest carbon (C) stocks.
Gerald Kalt +5 more
doaj +1 more source