Results 191 to 200 of about 610,169 (309)

Rerum Novarum: Educational resource to promote occupational health and rights in the industrial age of artificial intelligence. [PDF]

J Educ Health Promot
Persaud E.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

International Expert Priorities for Promoting Recovery and Coercion-Free Practices in Psychosocial Disability: A Delphi Study. [PDF]

Alpha Psychiatry
Atzeni M, Cossu G, Tusconi M, Kurotschka PK, Zreik T, Nardi AE, Khurshudyan M, Kalcev G, Ciccu S, Gureje O, Ghachem R, Gonzalez CIA, Carta MG.   +12 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The motherhood penalty and absence of leisure rights: legal examination and institutional response under China's three-child policy. [PDF]

Front Sociol
Huang T, Hu Z.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A Comparative Analysis of the Critical Resilience and Gender Equity of Mothers Impacted by Albinism: Promising Practices From Tanzania and South Africa. [PDF]

Public Health Chall
Reimer-Kirkham S, Astle B, Ero I, Beaman L, de Waal M, Ibhawoh B, Imafidon E, Kromberg J, Leech R, Mazibuko N, Mgijima-Konopi I, Mooa RS, Msipa D, Senkoro P, Sharma S, Tettey W, Tjope M, Wiafe B, Buyco M, Strobell E.   +19 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Book review of Sealy, Thomas, Uberoi, Varun and Meer, Nasar (eds.) 2024. The resilience of multiculturalism: Ideas, politics, practice. Edinburgh: Edinburgh University Press. 328 pp.

Nordic Journal of Migration Research
Östen Wahlbeck
doaj   +1 more source