Results 181 to 190 of about 1,400 (241)

Advancing Dry Electroencephalography With Scalable, Soft, and Transcranial Magnetic Stimulation‐Compatible Ti3C2Tx MXene Electrodes for Research and Clinical‐Grade Applications

open access: yesAdvanced Science, EarlyView.
Dry soft Ti3C2Tx MXene electroencephalography (EEG) electrodes provide low impedance (2.1 ± 1.8 kΩ at 10 Hz), long‐term stability, and enable safe simultaneous EEG and transcranial magnetic stimulation (TMS). Across scalp sites, hair types, and recording paradigms, including steady state visual evoked potentials (SSVEP), clinical EEG, and mobile EEG ...
Sneha Shankar   +17 more
wiley   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

open access: yesAdvanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou   +22 more
wiley   +1 more source

Developing a Single‐Cell Spatial Transcriptomics Workflow for In Vivo Evaluation of Implanted Biomaterials

open access: yesAdvanced Science, EarlyView.
This work establishes a standardized, high‐resolution spatial transcriptomics workflow for characterizing host responses to biomaterial implants. Using the 10× Xenium platform, the pipeline integrates spatial mapping, subclustering, and functional enrichment to resolve immune and stromal cell organization at single‐cell resolution, enabling ...
Alex H.P. Chan   +7 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song   +12 more
wiley   +1 more source

International Relations as a Social Science: Rigor and Relevance

The ANNALS of the American Academy of Political and Social Science, 2005
Progress in the study of international politics depends on systematic, rigorous theory and empirical testing. International Relations is most useful when scholars can identify with some confidence the causal forces that drive foreign policy and international interactions, not when they use their detailed empirical knowledge to offer opinions, however ...
Frieden, Jeffry, Lake, David A.
openaire   +2 more sources

The Social Costs of Methodological Rigor

Evaluation Review, 1984
This article argues that certain threats to validity arise from the social, rather than methodological, consequences of research design. The need for an evaluator to attend to both methodological and social concerns is demonstrated by an example where the unchecked effects of the social consequences of a methodologically rigorous research design ...
openaire   +1 more source

“Rigor for What?” Social Studies Teacher Conceptions and Enactments of Instructional Rigor

The Social Studies, 2017
ABSTRACTTaken from a larger qualitative study, this article argues that rather than an encompassing uniform definition, rigor, as understood and enacted by social studies teachers, exists on a complicated spectrum. Teacher placement on this spectrum was influenced by teacher life experience, teacher interpretation of student need, pedagogy employed ...
openaire   +1 more source

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