Results 211 to 220 of about 17,519,433 (394)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Enhancing social science research on cyberbullying through human machine collaboration. [PDF]

Sci Rep
Baños-Ramos A, Reneses M, Pérez J, Valverde G, Awad E, López GL, Castro M.   +6 more
europepmc   +1 more source

14th Annual Idaho Public Policy Survey [PDF]

, 2003
Social Science Research Center, Boise State University
core   +1 more source

Social Problems and Social Science [PDF]

Science, 1966
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

On the future of social sciences and humanities – a pragmatic perspective [PDF]

, 2016
Ronald J. Pohoryles, Andrew Sors
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Rethinking the Blue Economy: Integrating social science for sustainability and justice. [PDF]

NPJ Ocean Sustain
Penca J, Ertör I, Ballesteros M, Briguglio M, Kowalewski M, Pauksztat B, Cepić D, Piñeiro-Corbeira C, Vaidianu N, Villasante S, Pascual-Fernández JJ.   +10 more
europepmc   +1 more source

Nomophobia And Other Psycho-social Factors Affecting Sleep Quality Among Undergraduate Health Sciences Students: A Cross-Sectional Study [PDF]

Muhammad Khan, Maryam Pyar Ali Lakhdir, Iqbal Azam, Nargis Asad   +3 more
openalex   +1 more source

Mobile Technology As A Promising Tool For Health Research In The Social Sciences [PDF]

, 2012
Marcos Reyes-Estrada
openalex   +1 more source