Results 131 to 140 of about 6,554,473 (312)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Poset sensitivity analysis reveals post 2020 changes in human development index components
iScienceSummary: This study assesses the sensitivity of the Human Development Index (HDI) using partially ordered set (poset) analysis. Unlike conventional methods, such as correlation, dominance, or simulation-based techniques, poset analysis maintains the ...
Francesc Martori, Tadashi Hirai
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
COVID-19 test-to-stay program for K-12 schools: Opt-in versus opt-out consent model
iScienceSummary: The Centers for Disease Control and Prevention promoted the Test-to-Stay (TTS) program to facilitate in-person instruction in K-12 schools during COVID-19.
Anton Ivanov +8 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Methods matter: Exploring how expectations influence common actions
iScienceSummary: Behavior in controlled laboratory studies is not always representative of what people do in daily life. This has prompted a recent shift toward conducting studies in natural settings.
Andrea Ghiani, David Mann, Eli Brenner
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Assessing the impact of armed conflict on the progress of achieving 17 sustainable development goals
iScienceSummary: With global armed conflicts reaching a 30-year high in 2023, understanding their impact on the progress of Sustainable Development Goals (SDGs) is crucial.
Di Wang +3 more
doaj +1 more source