Results 171 to 180 of about 2,590,984 (266)

Science on the Social Anvil [PDF]

Nature, 1970
openaire   +2 more sources

Underrepresented transition factors from social sciences in energy and emissions modeling

Kunnas S, Trutnevyte E.
europepmc   +1 more source

Evaluation as a translational resource: Bridging social sciences with clinical and translational sciences to advance university, health system, and community initiatives. [PDF]

J Clin Transl Sci
Sperling J, Muhigaba PB, Quenstedt S, Wyman Roth N, Brown A, McClernon FJ.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Publication bias in the social sciences since 1959: Application of a regression discontinuity framework. [PDF]

PLoS One
Jerke J, Velicu A, Winter F, Rauhut H.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Representation gap for transition factors from social sciences in energy and emissions modeling

Kunnas S, Trutnevyte E.
europepmc   +1 more source

Pandemic preparedness: why humanities and social sciences matter. [PDF]

Front Public Health
Frampton S, Orievulu K, Matthews PC, Giubilini A, Hordern J, Burns L, Elias S, Friederich E, Majozi N, Martin S, Stevenson A, Vanderslott S, Seeley J.   +12 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Constructing Schwartz values framework using the Rokeach values survey: Human value measurement in the longitudinal internet survey for social sciences. [PDF]

PLoS One
Smallenbroek O, Leijen I, Stanciu A, van Herk H, Bardi A.   +4 more
europepmc   +1 more source