Results 211 to 220 of about 17,001,074 (407)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Ten facts from critical and interpretive social sciences for environmental research. [PDF]

iScience
Montana J, Welden EA, Anderson LM, Bennett A, Byfuglien A, Bhalla S, Fair H, Greenhough B, Hafferty C, Hirons M, Kumeh EM, Maguire-Rajpaul V, McDermott CL, Mulyani M, Picot L.   +14 more
europepmc   +1 more source

Reproducibility in the Social Sciences. [PDF]

Annu Rev Sociol, 2022
Moody JW, Keister LA, Ramos MC.
europepmc   +1 more source

ISLAM AS A CULTURAL CAPITAL IN INDONESIA AND THE MALAY WORLD: A Convergence of Islamic Studies, Social Sciences and Humanities [PDF]

, 2017
Amin Mahir Abdullah
openalex   +1 more source

Social Problems and Social Science [PDF]

Science, 1966
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Impostor phenomenon and its association with perceived stress and anxiety among students in medical and social sciences at a Swedish university. [PDF]

Front Med (Lausanne)
Jansson A, Boman J, Schéle I, Holmström S, Rozental A, Semb O, Fahlström M, Stenman L, Bitar A, Lindquist D.   +9 more
europepmc   +1 more source

Short text classification with machine learning in the social sciences: The case of climate change on Twitter. [PDF]

PLoS One, 2023
Shyrokykh K, Girnyk M, Dellmuth L.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The social sciences in climate assessments in the United States. [PDF]

Clim Change
Maxwell KB, Shacklette M, Eisenhauer E, Scheetz AA, Marino E, Zycherman A.   +5 more
europepmc   +1 more source