Results 61 to 70 of about 2,487,886 (263)

Early warning of regime switching in a complex financial system from a spillover network dynamic perspective

open access: yesiScience
Summary: Early warning of regime switching in a complex financial system is a critical and challenging issue in risk management. Previous research has examined regime switching through analyzing the fluctuation features in a single point in time series ...
Sufang An, Xiangyun Gao, Feng An, Tao Wu
doaj   +1 more source

Exploring informed consent in HIV clinical trials: A case study in Uganda

open access: yesHeliyon, 2016
Introduction: In settings with low literacy levels ensuring that participants are fully-informed before they consent to participate in clinical trials is a challenge.
Agnes Ssali, Fiona Poland, Janet Seeley
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Bluetooth-sensed social presence is associated with immediate vigor and delayed fatigue: A multi-method time series analysis

open access: yesiScience
Summary: Social interactions affect emotional well-being, yet their temporal dynamics remain understudied in natural settings. We examined these patterns through an experience sampling method study with 80 participants over two weeks (k = 3,716 ...
David Willinger, Stefan Stieger
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

"Hard Sciences" e "Social Sciences": Um Enfoque Organizacional

open access: yesDados: Revista de Ciências Sociais, 1998
The article offers an empirically guided discussion of the organizational model which Whitley has proposed for analyzing scientific fields. The central, empirically tested dimensions of the model refer to a consensus-forming process.
Beato F. Claudio C.
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa

open access: yesiScience
Summary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield   +2 more
doaj   +1 more source

Science and Social Media [PDF]

open access: yesStem Cells Translational Medicine, 2019
Summary He Jiankui et al. conducted an experiment that resulted in the birth of the first human babies with germline gene editing. Initial and predominant communications of their work occurred via social media and outside of the norms for reviewing, approving, and engaging around work in science.
openaire   +3 more sources

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