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Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
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Advanced Biology, EarlyView.The successful in situ polymerization of microtubules in giant polymer‐lipid hybrid vesicles is illustrated. The microtubules formed in the giant hybrid vesicles exhibit different morphologies including lumenal network formation and membrane association. Abstract Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a
Paula De Dios Andres +4 more
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Artificial societies and generative social science
Artificial Life and Robotics, 1997What is anartificial society? What can such models offer the social sciences in particular? We address these general questions, drawing brief illustrations from the specific artificial society we call “Sugarscape.”
Joshua M. Epstein, Robert L. Axtell
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Generalizations in the Social Sciences
American Journal of Sociology, 1953There is a tendency to overgeneralize in sociology and social psychology, and the logical conditions for extension of conclusions outside the data are not fulfilled. As a result, replications often do not verify the original studies. Some suggestions for improving research design to achieve consistent replications are discussed: the use of theory ...
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A general framework for social science
Policy Sciences, 1972It is possible to construct a basic framework that potentially accommodates the interactions of all biological, biosocial, cultural and situational determinants of behavior. While specific problems will require changes of detail, a single structure of interactions for all problems increases the additive possibilities of the field, and makes feasible ...
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Social networks generate interest in computer science
ACM SIGCSE Bulletin, 2006For forty years programming has been the foundation of introductory computer science. Despite exponential increases in computational power during this period, examples used in introductory courses have remained largely unchanged. The incredible growth in statistics courses at all levels, in contrast with the decline of students taking ...
Owen Astrachan +4 more
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Incorporating general intelligence into epidemiology and the social sciences [PDF]
Intelligence, 1997 The purpose of this article is to demonstrate the value of examining a variety of pressing behavioral, medical, and social phenomena as they relate to gradations in general intelligence. Although few (if any) variables in the social sciences can compete with the construct of general intelligence in its ability to forecast an array of socially valued ...
David Lubinski, Lloyd G. Humphreys
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Agent_Zero and generative social science
2015 Winter Simulation Conference (WSC), 2015Agent_Zero is a formal alternative to the rational actor model that has dominated social science since the 1940s. This software individual is the first to be endowed with distinct affective, deliberative, and social modules. Grounded in neuroscience, these internal facets interact to produce far-from-rational individual behavior.
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Dialectic as a General Method of Social Science: Varieties of Social Science Experience
1981There can be little doubt that what we have come to call scientific method has undergone significant transformation and development in this century and the last. Nowhere has this been more apparent than in the social sciences. If the essence of method be identified with control, quantification, and measurement, then the ability of the social sciences ...
Richard O. Mason, Ian I. Mitroff
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Historical Generalization and Social Science Education
The Social Studies, 1975(1975). Historical Generalization and Social Science Education. The Social Studies: Vol. 66, No. 5, pp. 214-217.
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