Results 31 to 40 of about 539,779 (314)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community

Journal of Investigative Medicine High Impact Case Reports, 2023
Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient.
Killen H. Briones-Claudett MD, MSc, H. Mónica Briones-Claudett MSc, MD, Roger Alexander Murillo Vasconez MD, Cynthia K. Bajaña Huilcapi MD, Carolina del Rosario Rivera Salas MD, Jaime Benitez Sólis MD, MSc, Domenica F. Estupinan Vargas MD, Henry Parra-Vera MSc, Killen H. Briones Zamora MS, Diana C. Briones Marquez MD, Michelle Grunauer MD, PhD   +10 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Lipid profile of healthy women during normal pregnancy [PDF]

Journal of Medical Biochemistry, 2009
The four basic lipid indexes (Chol, Trig, HDL-C and LDL-C) increase during pregnancy, following different rates of increase. Among the four analytes triglycerides show the largest increase and HDL-C the smallest.
Diareme Margarita, Karkalousos Petros, Theodoropoulos Georgos, Strouzas Stefanos, Lazanas Nikos   +4 more
doaj  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Modeling the pro-inflammatory tumor microenvironment in acute lymphoblastic leukemia predicts a breakdown of hematopoietic-mesenchymal communication networks

Frontiers in Physiology, 2016
Lineage fate decisions of hematopoietic cells depend on intrinsic factors and extrinsic signals provided by the bone marrow microenvironment, where they reside.
Jennifer Enciso, Jennifer Enciso, Hector Mayani, Luis Mendoza, Rosana Pelayo   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Intraperitoneal metastases from cutaneous melanoma in a 2-year-old girl: A case report

Journal of Pediatric Surgery Case Reports
Introduction: Cutaneous melanoma represents less than 1 % of all pediatric malignancies, with an incidence of 4.9 cases per million in children aged 0–4 years. Intraperitoneal metastasis is exceptionally rare in this population.
García-Ledezma Arnold, Tirado-Camarena Salvador, Izabal-Tinajero Neivy Marely, Román-Matus Alexis, García-Calderón Cesar Iván, Torres-Salazar Quitzia Libertad   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Social Infrastructure for Hometown Security: Advancing the Homeland Security Paradigm [PDF]

, 2009
This article appeared in Homeland Security Affairs (May 2009), v.5 no.2The nation's homeland security strategy calls on federal, state, and local governments, businesses, communities and individuals across the country to work together to achieve a shared
Bach, Robert, Kaufman, David J.
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