Results 51 to 60 of about 16,775,355 (287)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development and Validation of a Self-Efficacy Scale with Writing and Social Factors

Asian Journal of Assessment in Teaching and Learning, 2016
As a useful base for scale development, self-efficacy construct can be used in measuring competency and self-perception of individuals in their social behavior and academic achievements. The aim of this study was to develop a self-efficacy scale with two
Sadegh Soheili Anaraki, Seyed Mohammad Reza Amirian, Moslem Zolfagharkhani   +2 more
doaj  

Social anxiety and its effect on self-efficacy among family medicine residents in Riyadh

Journal of Family Medicine and Primary Care, 2018
Background: Social anxiety is a common disorder that characterized by fear of social situations. Social anxiety disorder causes several problems including alcohol abuse. Its prevalence is high, and it affects work and education.
Mohammed Abdullah Al-Ruwaili, Yousef Abdullah Al-Turki, Abdulrahman Alardan   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Perfectionism, self-efficacy, and aspiration level: Differential effects of perfectionistic striving and self-criticism after success and failure. [PDF]

, 2008
Despite over 15 years of research on multidimensional perfectionism, it is still unclear how different forms of perfectionism are related to self-efficacy, aspiration level, and reactions to success and failure in performance situations.
Stoeber, Joachim, Wood, Kerry V., Hutchfield, Jemeela   +2 more
core   +1 more source

Exploring the relationship between self-efficacy and coping amongst undergraduate students [PDF]

, 2004
Report of a CELT project on supporting students through innovation and researchThis study investigates the relationship between self-efficacy and coping amongst first year sports studies students.
Devonport, Tracey J., Lane, Andrew M.
core   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Regulatory Emotional Self-Efficacy and Social Self-Efficacy: Validation evidence of related constructs

, 2023
This study aimed to seek evidence of validity for the Self-Efficacy Scale for Emotional Regulation (SESER) using the relationship with the Emotional Self-Regulation Scale (ESRE) and the Social Self-Efficacy Scale (SSES). Participants included a total of 549 students aged between 13 and 23 years old (M = 16.82, SD = 1.551) from the Brazilian ...
Iaochite, Roberto Tadeu, Noronha, Ana Paula Porto, Casanova, Daniela Couto Guerreiro, dos Santos, Acácia Aparecida Angeli, Azzi, Roberta Gurgel   +4 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source