Results 221 to 230 of about 10,367,407 (327)

LINC: a framework for maintaining high-quality passive data in digital phenotyping studies. [PDF]

Sci Rep
Calvert E, Lane E, Flathers M, Torous J.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Teaching Experience Correlates with Enhanced Social Cognition in Preschool Teachers. [PDF]

J Intell
Molina-Mateo D, Leiva-Cisterna I, Barraza P.   +2 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Digital biomarkers in the diagnosis of social anxiety disorder: a scoping review. [PDF]

BMC Psychiatry
Qiao FQ, Dong WQ, Wang XN, Sun Q.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Smartphone-Based Digital Phenotyping Across Health Conditions: Scoping Review.

J Med Internet Res
Dumas A, Hokayem J, Goodman G, Venkatasubramanian K, Chai P.   +4 more
europepmc   +1 more source

Pressure sensing technology for remote control: Can we motivate users to stay on the learning curve? [PDF]

PLoS One
Crowe EM, Castle-Green S, Beecroft D, Caleb-Solly P.   +3 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Personalizing ecological momentary intervention for substance use disorders through data-driven decision rules. [PDF]

Front Psychiatry
Kwon M, Song JY, Hwang JY, Seong SJ, Park KJ, Jo YT, Kim YJ, Ahn ME, Lee SK.   +8 more
europepmc   +1 more source