Results 41 to 50 of about 5,392,924 (294)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

‘They already operated like it was a crisis, because it always has been a crisis’: a qualitative exploration of the response of one homeless service in Scotland to the COVID-19 pandemic

Harm Reduction Journal, 2021
Background The COVID-19 pandemic has necessitated unprecedented changes in the way that services are delivered to individuals experiencing homelessness and problem substance use.
Tessa Parkes, Hannah Carver, Wendy Masterton, Danilo Falzon, Josh Dumbrell, Susan Grant, Iain Wilson   +6 more
doaj   +1 more source

Investigating Trajectories of Social Recovery in Individuals with First Episode Psychosis:A Latent Class Growth Analysis [PDF]

, 2015
Background Social disability is a hallmark of severe mental illness yet individual differences and factors predicting outcome are largely unknown. Aim To explore trajectories and predictors of social recovery following a first episode of psychosis (FEP).
Amos, Tim, Birchwood, Max, Christopher, Rose, Coker, Sian, Everard, Linda, Fowler, David, Freemantle, Nicholas, Hodgekins, Joanne, Jones, Peter, Lester, Helen, Marshall, Max, Sharma, Vimal, Singh, Swaran   +12 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Primary Peritoneal Serous Cancer: A Case Report of a Tumor in the Rectovaginal Septum

Case Reports in Oncological Medicine
Peritoneal cancer is the invasion by malignant cells of serous membrane that lines the abdominal cavity, the viscera, and the coelom of the amniotes. Histologically, it is indistinguishable from ovarian counterpart, although in the former, it commonly ...
Analy Herrera-Torres, Carlos Guadalupe Parra-Torres, Gabriela C. Alamilla García, María del Rocío Thompson Bonilla, Oscar Manuel García Córdova, Alfredo Padilla Martínez, Rodolfo Iván Lara Ruíz, Esther Ramírez Moreno   +7 more
doaj   +1 more source

View from the top: Involvement of Namibia’s health ministry in laboratory quality improvement

African Journal of Laboratory Medicine, 2014
No abstract available.
Mary N. Mataranyika, Landine K. Beukes
doaj   +1 more source

“You know, we can change the services to suit the circumstances of what is happening in the world”: a rapid case study of the COVID-19 response across city centre homelessness and health services in Edinburgh, Scotland

Harm Reduction Journal, 2021
Background The COVID-19 pandemic has necessitated unprecedented changes in the way that health, social, and housing services are delivered to individuals experiencing homelessness and problem substance use.
Tessa Parkes, Hannah Carver, Wendy Masterton, Danilo Falzon, Joshua Dumbrell, Susan Grant, Iain Wilson   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Applying a new concept of embedding qualitative research: an example from a quantitative study of carers of people in later stage dementia

BMC Geriatrics, 2019
Background Qualitative methods are increasingly included in larger studies to provide a richer understanding of people’s experience. This paper explores the potential of using a novel approach to embedded qualitative design as part of an observational ...
Michele Abendstern, Karen Davies, Helen Chester, Paul Clarkson, Jane Hughes, Caroline Sutcliffe, Fiona Poland, David Challis   +7 more
doaj   +1 more source

The Fog Makes Sense: Enabling Social Sensing Services With Limited Internet Connectivity

, 2017
Social sensing services use humans as sensor carriers, sensor operators and sensors themselves in order to provide situation-awareness to applications.
Gupta, Harshit, Mayer, Ruben, Ramachandran, Umakishore, Saurez, Enrique   +3 more
core   +1 more source