Results 71 to 80 of about 5,429,136 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A new system for better employment and social outcomes: report of the Reference Group on Welfare Reform to the Minister for Social Services [PDF]

This review’s purpose was to identify how to make Australia’s welfare system fairer, more effective, coherent and sustainable and encourage people to work.
Department of Social Services (Australia), Patrick McClure   +1 more
core  

The Social and Economic Value of Human Services [PDF]

, 2011
This paper examines publicly-funded human services and highlights a body of evidence that speaks to both the social and economic value for society when investments are made into human services.
Amy Rynell, Amy Terpstra, Ian Mobley, Lindy Carrow   +3 more
core  

Policy and service responses to rough sleeping among older people [PDF]

, 2000
Rough sleeping in Britain has a long history, and interventions have alternated between legal sanctions and humanitarian concern. This paper critically examines recent changes in homeless policies and services, with particular reference to the needs of ...
Crane, M., Warnes, A.M.
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Support Workers in Community Mental Health Teams for Older People: Exploring Sources of Satisfaction and Stress

Journal of Long-Term Care, 2019
Context: Support workers play an essential role in multidisciplinary community mental health teams for older people (CMHTsOP) in England. However, little is known about how they perceive their role or the impact this has on their levels of stress ...
Rowan Jasper, Mark Wilberforce, Michele Abendstern, Sue Tucker, David Challis   +4 more
doaj   +3 more sources

Part Three. Redistributive Impact of Social Services (Summary) [PDF]

, 1997
Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej ...

core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Short-term acute outcomes by clinical and socioeconomic characteristics in adults with SARS-CoV-2: a population-based cohort study focused on the first two years of the COVID-19 pandemic

Archives of Public Health
Background The COVID-19 pandemic disproportionately affected vulnerable populations in terms of comorbidity and socioeconomic disadvantage, both between and within countries.
Alice Corsaro, Federico Banchelli, Rossella Buttazzi, Enrico Ricchizzi, Carlo Gagliotti, Elisa Fabbri, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Nicola Caranci, Elena Berti   +11 more
doaj   +1 more source

Care services, multinational companies and expanding European markets [PDF]

, 2010
Social services are becoming a major issue at European level although recognition of importance of social services as publicly-run services unclear. Multinational care companies are operating in several distinct European sub-markets.
Lethbridge, Jane
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