Results 201 to 210 of about 12,386,416 (381)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Application of neurobiofeedback therapy technology on social skills and emotion regulation in children with autism spectrum disorder. [PDF]

World J Psychiatry
Wang XN, Luo WW, Li HY, Zhang T.
europepmc   +1 more source

The impact of extracurricular activities involvement on junior secondary one students' self-esteem and social skills

, 2011
Euji Lam Hiu-fung
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Bridging research and practice: a pilot trial of an adapted social skills program for autism in public services. [PDF]

Front Psychiatry
Mairena MA, Alcover C, Arias-Pujol E, Díez-Juan M, Mezzatesta Gava M, Elias N, Sentenach A, Elias M, Piera E, González M, Solomon M, Aranbarri A.   +11 more
europepmc   +1 more source

Multicultural Competence For Doing Social Justice: Expanding Our Awareness, Knowledge, And Skills [PDF]

, 2012
Susan V. Iverson
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Reasoning-based LLMs surpass average human performance on medical social skills. [PDF]

Sci Rep
Alohali KI, Almusaeeb LA, Almubarak AA, Alohali AI, Muaygil RA.   +4 more
europepmc   +1 more source

Social, Spatial, and Skill Mismatch Among Immigrants and Native-Born Workers in Los Angeles

, 2000
Manuel Pastor, Enrico A. Marcelli
openalex   +1 more source

Reviews of Social Embodiment for Design of Non-Player Characters in Virtual Reality-Based Social Skill Training for Autistic Children [PDF]

, 2018
Jewoong Moon
openalex   +1 more source