Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Pathways From Early Vocabulary to School-Age Social Skills: Findings From a Large Prospective Cohort Study. [PDF]
Dev SciWieczorek K +3 more
europepmc +1 more source
Non-Cognitive Skills as a Resource for Social Participation of the Population
Irina Vorobeva
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The mediating role of emotion regulation and cognitive flexibility in the relationship between cooperative learning and social skills of students: a cross-sectional study. [PDF]
BMC PsycholMa W, Motevalli S, Kuang X, Song R.
europepmc +1 more source
Effect of Social Skills Training: Social Interaction Capabilities towards Social Isolation Clients [PDF]
, 2017 Hanik Endang Nihayati +3 more
openalex
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Intergenerational effects of parental positive childhood experiences on social skills development in Chinese preschoolers: the moderating role of the home-rearing environment. [PDF]
Front PsycholYuan X +7 more
europepmc +1 more source