Results 111 to 120 of about 916,159 (305)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
22nd Conference on Software Engineering Education and Training [PDF]
Software engineering courses often include some form of project, aimed at bridging the theory-practice gap. These projects tend to emphasize technical topics.
Hans Van Vliet +2 more
core
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
How to Boost Engineering Support Via Web 2.0 - Seeds for the Ares Project...and/or Yours? [PDF]
, 2010 The Mission Operations Laboratory (MOL) at Marshall Space Flight Center (MSFC) is responsible for Engineering Support capability for NASA s Ares launch system development.
Scott, David W.
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
EPICS: A Service Learning Program at Butler University [PDF]
, 2005 In this paper we present our experiences teaching EPICS (Engineering Projects In Community Service) at Butler University, a small, private university, from within the Department of Computer Science and Software Engineering.
Linos, Panos K, Sorenson, Jonathan P
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Disciplined Delivery and Organizational Design Maturity: A Socio-Technical Evolutionary Journey
SystemsThe increasing digitalization of the world underscores the critical importance of both social and technical aspects in software engineering practice. While prior research links socio-technical congruence (STC) to positive workstream outcomes, the current
Miguel A. Oltra-Rodríguez +3 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Understanding Collaboration in Global Software Engineering (GSE) Teams with the Use of Sensors: Introducing a Multi-sensor Setting for Observing Social and Human Aspects in Project Management [PDF]
, 2017 Georgios Dafoulas +4 more
openalex +1 more source