Results 161 to 170 of about 1,206,543 (334)

Cultural heritage preservation through ontology-based semantic search systems

open access: yesConservation Science in Cultural Heritage
The aim of this study was to develop a semantic search system for Khmer stone castles in the Greater Mekong Subregion (GMS), in alignment with UNESCO's cultural heritage preservation guidelines.
Wirapong Chansanam   +7 more
doaj   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

open access: yesFEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang   +11 more
wiley   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

open access: yesFEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda   +15 more
wiley   +1 more source

Assessing habitat suitability for aoudad (Ammotragus lervia) reintroduction in southeastern morocco to promote ecotourism

open access: yesScientific African
The objective of this study is to address the complex task of identifying optimal locations for reintroducing Ammotragus lervia in a semi-arid area in the Eastern High Atlas of Morocco, considering three topographical factors.
Lahbib Naimi   +4 more
doaj  

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Developing Lexicons for Enhanced Sentiment Analysis in Software Engineering: An Innovative Multilingual Approach for Social Media Reviews [PDF]

open access: gold
Zohaib Ahmad Khan   +6 more
openalex   +1 more source

Meet your Maker: A Social Identity Analysis of Robotics Software Engineering [PDF]

open access: green, 2023
Carlos Gavidia-Calderon   +5 more
openalex   +1 more source

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