Results 71 to 80 of about 1,317,898 (360)

Integrated VPN Solution [PDF]

Jisuanji kexue
Aimed at the problems that the traditional VPN does not support the carrying of multiple data types,lack of security of data,and overweight label edge devices,an integrated VPN solution is proposed..The design includes the establishment of GRE VPN,the ...
TAO Zhiyong, YANG Wangdong
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Sustainable Software Engineering: Concepts, Challenges, and Vision

ACM Transactions on Software Engineering and Methodology
Information and communication technology (ICT) offers promising opportunities to address global sustainability challenges such as climate change and social inequality by enabling energy savings and social innovations.
C. König, Daniel J. Lang, Ina Schaefer
semanticscholar   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Case Study On Social Engineering Techniques for Persuasion [PDF]

, 2010
There are plenty of security software in market; each claiming the best, still we daily face problem of viruses and other malicious activities. If we know the basic working principal of such malware then we can very easily prevent most of them even ...
Hasan, Mosin, Prajapati, Nilesh, Vohara, Safvan   +2 more
core   +3 more sources

Intersectional Software Engineering as a Field

Software
Intersectionality is a concept used to explain the power dynamics and inequalities that some groups experience owing to the interconnection of social differences such as in gender, sexual identity, poverty status, race, geographic location, disability ...
Alicia Julia Wilson Takaoka, Claudia Maria Cutrupi, Letizia Jaccheri   +2 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]

, 2019
In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas, Ayala Palenzuela, Rosa María, Capobianco Uriarte, María De Las Mercedes, Criado Rodríguez, Javier, Iribarne Martínez, Luis Fernando, Piedra Fernández, José Antonio, Rodríguez Gracia, Diego   +6 more
core   +1 more source

Privacy through Anonymisation in Large-scale Socio-technical Systems: Multi-lingual Contact Centres across the EU [PDF]

, 2016
Large-scale socio-technical systems (STS) inextricably interconnect individual – e.g., the right to privacy –, social – e.g., the effectiveness of organisational processes –, and technology issues —e.g., the software engineering process.
Cerno, Italo, Cevenini, Claudia, Denti, Enrico, Omicini, Andrea   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source