Results 101 to 110 of about 1,982,798 (318)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

2007 Photo Gallery: The 19th National Symposium on Doctoral Research in Social Work

, 2007
The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social ...
Ohio State University. College of Social Work
core  

The essence and purpose of the social state in the context of the legal experience of modern Ukraine: theoretical and legal analysis

Bulletin of Kharkiv National University of Internal Affairs
The concept of the social state is one of the elements of the constitutional identity of Ukraine. In the context of the Constitution of Ukraine, the social state is endowed with a number of important legal features and characteristics that can be ...
S. S. Polesov
doaj   +1 more source

Social Media as Fragile State

Proceedings of the Annual Hawaii International Conference on System Sciences
Social media platforms are grappling with how to respond to hate speech, misinformation, and political manipulation in ways that address human rights, free speech, and equality. As independent ‘states’, they are enacting their own rules of conduct, deriving their own ‘laws’, convening their own extrajudicial self regulatory institutions, and ...
Haythornthwaite, Caroline A, Mai, Philip, Gruzd, Anatoliy   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

South Carolina social studies college- and career-ready standards

, 2021
The purpose of academic standards is to provide the basis for the development of local curricula and statewide assessment. The social studies standards development process was designed to develop clear, rigorous, and coherent standards that will prepare ...
South Carolina State Department of Education
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Proceedings Front Matter: 3rd National Symposium on Doctoral Research in Social Work

, 1987
The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social WorkProceedings title page, table of contents,foreword, introduction, and comments by Dagmar ...
Ohio State University. College of Social Work
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source